EFFECT OF THE PROSTAGLANDIN SYNTHETASE INHIBITOR INDOMETHACIN ON 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY TUMORIGENESIS IN RATS FED DIFFERENT LEVELS OF FAT

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (8) , 3559-3562
Abstract
The effect of the prostaglandin synthetase inhibitor indomethacin on the dietary fat enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis was examined in female Sprague-Dawley rats. Rats were fed either a normal-fat or high-fat diet (5 or 18% corn oil, respectively) with or without 0.004% indomethacin, starting 3 days after a single intragastric intubation of 5 mg 7,12-dimethylbenz(a)anthracene. Indomethacin completely blocked the stimulatory effect of fat on tumorigenesis, as measured by a decreased tumor incidence, a decreased number of tumors per group, a decreased tumor size, and an increased latency. No effect of indomethacin was observed in rats fed the normal-fat diet. At least part of the stimulatory effect of polyunsaturated fat on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis may be mediated through an increased synthesis of prostaglandins.