Further Therapeutic Experience With Pralidoximes in Organic Phosphorus Poisoning

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Abstract
A clinical evaluation has been made of 24 cases of organic phosphorus poisoning treated with atropine and pralidoxime chloride or iodide. The use of pralidoxime in three other patients who were not poisoned is presented. Response to treatment was most dramatic in parathion poisoning. Considerable benefit was evident in Phosdrin poisoning, but less so than in parathion poisoning. Experience with poisoning from tetraethyl pyrophosphate and malathion showed promise, but was insufficient to justify any final evaluation. Side effects were minimal. In severe poisonings the use of cholinesterase reactivators was justified on clinical impression alone, even when the history of exposure was incomplete or had not been obtained at the time of most severe signs and symptoms.

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