ACID RELEASES MOTILIN FROM HUMAN DUODENUM INVITRO

  • 1 January 1977
    • journal article
    • research article
    • Vol. 24  (6) , 456-457
Abstract
The effect of HCL and NaOH on motilin release from human duodenal mucosa was studied in vitro. Tissue was incubated in 2 ml chambers continuously perfused with medium and was exposed repeatedly to the stimuli. Motilin released into the medium was determined by a specific radioimmunoassay. Whereas alkalinization abolished basal motilin release, acidification resulted in a 14-fold increase of peptide secretion. Motilin secretion apparently can be stimulated in vitro, and the perfusion system described may be a useful tool in studying the mechanism of gastrointestinal hormone release.

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