WEGENER'S GRANULOMATOSIS—INCREASED INCIDENCE OR INCREASED RECOGNITION?

Open Access

1 February 1996

journal article
research article
Published by Oxford University Press (OUP) in Rheumatology

Vol. 35 (2) , 142-145
https://doi.org/10.1093/rheumatology/35.2.142

Abstract

We aimed to calculate the annual incidence of Wegener's granulomatosis (WG) in Norfolk (UK) and to compare the clinical spectrum of disease to that seen in tertiary centres in both the UK and USA. We also aimed to examine the seasonal onset of symptoms. This was a prospective study of all patients presenting with WG to a district hospital with a well-defined stable population (515 000) during the period 1988–1993. The annual incidence for WG in the adult population is 8.5/million (95% CI 5.2–12.9). These are the first incidence figures for a well-defined population and are higher than previously published. The clinical spectrum of disease in Norfolk was similar to that seen in tertiary centres and there is supportive evidence for a seasonal variation in the onset of symptoms (highest in winter).

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