Effects of Captopril on Plasma Atrial Natriuretic Polypeptide and the Renin Angiotensin System in Rats
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 9 (2-3) , 697-701
- https://doi.org/10.3109/10641968709164245
Abstract
We investigated the effects of captopril on the plasma atrial natriuretic polypeptide (ANP) level and the renin angiotensin system in rats. A single oral administration of captopril decreased the plasma ANP level and increased the plasma renin activity (PRA). Chronic administration of captopril for 2 weeks caused no changes in plasma ANP level, but PRA was increased. This suggests the hypothesis that the hemodynamic changes rather than changes in the renin angiotensin system caused by captopril may affect the plasma ANP level.Keywords
This publication has 4 references indexed in Scilit:
- Atrial natriuretic factor—a circulating hormone stimulated by volume loadingNature, 1985
- Renal responses to atrial natriuretic factor during converting enzyme inhibitionCanadian Journal of Physiology and Pharmacology, 1985
- Physiology: Cardiac peptides and the control of sodium excretionNature, 1984
- Renin-angiotensin system in genetically hypertensive mice.Japanese Circulation Journal, 1984