REGULATION OF ANTIBODY-RESPONSE IN DIFFERENT IMMUNOGLOBULIN CLASSES .6. SELECTIVE SUPPRESSION OF IGE RESPONSE BY ADMINISTRATION OF ANTIGEN-CONJUGATED MURAMYLPEPTIDES
- 1 January 1979
- journal article
- research article
- Vol. 123 (6) , 2709-2715
Abstract
The suppressive effect of antigen-conjugated muramylpeptides or 6-O-mycoloyl muramylpeptides selectively on induction of mouse Ig[immunoglobulin]E antibody [Ab] response was demonstrated. Pre-administration of DNP[dinitrophenylated]-mycoloyl muramylpeptides completely inhibited induction of the anti-DNP IgE Ab response with DNP-ovalbumin (DNP-OA). Selective suppression of the IgE response was due to induction of DNP-specific suppressor T [thymus-derived] cells by DNP-mycoloyl muramylpeptides; suppressor cells were radiosensitive. Pre-administration of OA-conjugated muramylpeptides partially inhibited the primary and secondary induction of an anti-OA IgE Ab response. The suppressor effect was due to induction of OA-specific suppressor T cells. Application of allergen-conjugated muramylpeptides as therapeutic agents in human allergic diseases was suggested.This publication has 11 references indexed in Scilit:
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