Highly Chemoselective Metal-Free Reduction of Tertiary Amides
- 13 December 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 130 (1) , 18-19
- https://doi.org/10.1021/ja077463q
Abstract
This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance.Keywords
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