Catalytic asymmetric synthesis of optically active alkenes by palladium-catalysed asymmetric reduction of racemic allylic esters with formic acid
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 15,p. 1767-1768
- https://doi.org/10.1039/cc9960001767
Abstract
Asymmetric reduction of racemic allyl ester, e.g. methyl 1-vinyl-1,2,3,4-tetrahydronaphth-1-yl carbonate, which contain two different alkyl groups at the α-position, with formic acid in the presence of 1 mol% of palladium catalyst coordinated with (R)-3-diphenylphosphino-3′-methoxy-4,4′-biphenanthryl [(R)-MOP-phen] ligand gives optically active terminal alkenes in up to 93% ee.Keywords
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