Effects of Cations on the Cariostatic Activity of Orthophosphates

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Abstract
Mono- and di-basic salts of Na, K and Ca orthophosphate incorporated in various proportions into a caries-producing diet in sufficient amounts to double the P content of this diet, were fed to groups of 30 rats for 90 days beginning when they were 8 days old. In comparison with the control group, the caries scores were reduced by 81%, 71% and 29% when the Na, K or Ca salts, supplied 2/3 of the P supplement, and 45% when these salts were added in equal amounts. Thus, Na and K orthophosphates were highly effective in the prevention of experimental caries in rats, while Ca orthophosphate is only slightly cariostatic. The Ca salt interfers with the action of Na and K orthoposphates when the 3 were fed together.

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