The effect of severe hypoglycemia upon cerebrospinal fluid formation, ventricular iodide clearance, and brain electrolytes in rabbits

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Abstract
Severe insulin-induced hypoglycemia in rabbits reduces CSF formation, but not ventricular I- clearance as measured by ventriculocisternal perfusion. Apparently, CSF production is ultimately glucose-dependent but ventricular I- clearance is not. Severe hypoglycemia apparently results in intracellular K+ loss within the brain and extracellular Na replaces lost intracellular K+. Hypoglycemia probably results in cellular ATP reduction which affects membrane Na-K-ATPase and the ability of the brain cell to maintain a K+ gradient. K+ levels in the CSF also rise consequent to hypoglycemia. Homeostatic mechanisms that maintain a constant CSF K+ are also affected by hypoglycemia.