The pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease
Open Access
- 1 April 2001
- journal article
- research article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 3 (4) , 265-275
- https://doi.org/10.1046/j.1462-5822.2001.00112.x
Abstract
The IgA1 protease secreted by the pathogenic Neisseriae cleaves Lamp1, a major integral membrane glycoprotein of lysosomes, and significantly reduces its steady‐state levels in an infected cell. IgA1...Keywords
This publication has 60 references indexed in Scilit:
- Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeaeCellular Microbiology, 2000
- Vesicle exocytosis stimulated by α-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+The EMBO Journal, 1998
- Biosynthetic Transport of a Major Lysosomal Membrane Glycoprotein, Lamp-1: Convergence of Biosynthetic and Endocytic Pathways Occurs at Three Distinctive PointsExperimental Cell Research, 1995
- Immunobiology of purified recombinant outer membrane porin protein I of Neisseria gonorrhoeaeMolecular Microbiology, 1994
- The lysosomal membrane glycoprotein lamp-1 is transported to lysosomes by two alternative pathwaysArchives of Biochemistry and Biophysics, 1992
- Construction of isogenic gonococci with variable porin structure: effects on susceptibility to human serum and antibioticsMolecular Microbiology, 1990
- Identification of two lysosomal membrane glycoproteins.The Journal of cell biology, 1985
- Gonococcal Infection: A Model of Molecular PathogenesisNew England Journal of Medicine, 1985
- Etiology, Manifestations and Therapy of Acute Epididymitis: Prospective Study of 50 CasesJournal of Urology, 1979
- Studies on Gonococcus Infection. XVII. IgA1-Cleaving Protease in Vaginal Washings from Women with GonorrheaThe Journal of Infectious Diseases, 1979