Resolution of derivatized acids and amines on JTB-X: A new urea bonded chiral stationary phase
- 1 January 1990
- Vol. 2 (2) , 124-127
- https://doi.org/10.1002/chir.530020210
Abstract
A new urea-bonded chiral stationary phase has been developed in our laboratory. This bonded phase has been shown to resolve N-terminal substituted amino acids and the carboxyl derivatized anti-inflammatory drugs. Typical α-value for dinitrobenzoyl phenylglycine was 1.7. Values for derivatized ibuprofen, naproxen, and fenoprofen were 2, 1.84, and 1.6, respectively. Further application of these studies to biologically active compounds such as peptides and drugs is in progress.Keywords
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