In VitroMetabolism of Dehydroepiandrosterone Sulfate in Foreskin, Abdominal Skin and Vaginal Mucosa
- 1 February 1968
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 28 (2) , 187-191
- https://doi.org/10.1210/jcem-28-2-187
Abstract
Newborn foreskin, abdominal skin from a normal and an anencephalic infant, and vaginal mucosa were incubated with dehydroepiandrosterone-7α-3H-sulfate (DHA - 7α- 3H-SO4) (ammonium salt). The substrate was converted to dehydroepiandrosterone (DHA) in all incubations, with the yield ranging from 5.7 to 14.2%, indicating the presence of steroid sulfatase in the tissues studied. Under the conditions of these incubations, 3β-hydroxysteroid dehydrogenase and 17β-reductase activity converted the metabolites into Δ4-androstene-3,17-dione (Δ4-A) and testosterone.This publication has 9 references indexed in Scilit:
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