Absorption of Radioactive Vitamin B12 after Total Gastrectomy

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Abstract
Twenty-five years ago Castle1 showed that the oral administration of normal gastric juice mixed with beef muscle to patients with pernicious anemia resulted in a hematologic response, although neither substance was effective by itself. This led to the concept that pernicious anemia is caused by deficiency of a gastric or "intrinsic factor" that normally reacts with an "extrinsic" or food factor to produce a substance necessary for hematopoiesis. The intrinsic factor was found to be present not only in normal human gastric juice but also in the intestinal and gastric mucosa of other animal species, particularly swine.2 Since 1929 a . . .