Effect of Metronidazole on the Radiocurability and Oxygenation of the C3HBA Tumor

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Abstract
O2 diffusion current was measured in the C3HBA mammary adenocarcinoma with a Pt microelectrode. An i.p. injection of 0.6 mg/g body weight of metronidazole caused an increase in the O2 diffusion current of roughly 2.5 times within 60 min after injection. The same tumor was also more radiosensitive when metronidazole was given prior to treatment with X-rays. The TCD5O''s [median tumor control doses] at 60 days after treatment were reduced by factors of 1.32 and 1.35 if the mice were injected with 0.6 and 0.3 mg/g, respectively, of metronidazole 30 min prior to irradiation. The higher dose of 0.6 mg/g was more effective than 0.3 mg/g at 4000 and 5000 rads of X-rays as determined by the number of tumor cures at 90 days after treatment.

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