A Model in Mice for the Study of the Early Death Phenomenon after Vaccination and Challenge with Rabies Virus

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Abstract
The reactions of mice were studied for 10 days after their vaccination with an inactivated rabies vaccine. The kinetics of their resistance to an intracerebral challenge and neutralizing antibody activity of their serum were determined daily. Protection began on the 4th day after vaccination and was approximately correlated with virus-neutralizing antibody titers from the 6th to the 10th day. In vaccinated mice still unprotected, death following the intracerebral challenge occurred earlier than in unvaccinated control mice. This early death phenomenon is proposed as a model for immunopathological study of reaction to rabies vaccines.

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