Mutagenicity of some benzidine congeners and their N‐acetylated and N,N′‐diacetylated derivatives in different strains of Salmonella typhimurium

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Abstract
The Ames Salmonella/microsome test was used to compare the mutagenic response of Salmonella typhimurium TA100, TA98, TA1538, and TA1535 to 12 benzidine derivatives, ie, benzidine, 3,3′‐dimethoxybenzidine, 3,3′‐dimethylbenzidine, 3,3′‐dichlorobenzidine, and the corresponding N‐ and W,W‐diacetylated derivatives. With a few exceptions, the mutagenic response to this series of compounds varied in the order TA98 > TA1538 > TA100 > TA1535 = 0, and the N‐monoacetylated derivatives were more mutagenic than either the parent diamines or the N,N′‐diacetyl derivatives. The relative mutagenicities of the parent amines for TA98 were 3,3′‐dichlorobenzidine > > 3,3′‐dimethoxybenzidine > benzidine > 3,3′‐dimethylbenzidine.

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