PERSISTENCE, IN THE MOUSE GUT AS AN IMPORTANT FACTOR IN ORAL IMMUNOGENICITY OF STRAINS OF V. CHOLERAE
- 1 June 1979
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 57 (3) , 325-333
- https://doi.org/10.1038/icb.1979.35
Abstract
Summary: The immue responses of mice following oral vaccination with two strains of live V. cholera have been examined. A strain which persisted in the small intestine was a superior local immunogen by comparison with another non‐persisting strain. Local persistence and the ability to induce a local immune response appeared to be correlated, since the two vibrio strain elicited identical responses when given parenterally.Keywords
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