Comparison of the In Vitro Host Range of Recombinant met-Interferon-con1, Interferon-α2a, and Interferon-β
- 1 March 1995
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon & Cytokine Research
- Vol. 15 (3) , 231-234
- https://doi.org/10.1089/jir.1995.15.231
Abstract
The antiviral activity of human r-metIFN-con1 was compared with that of IFN-α2a and IFN-β on a number of human, other primate, rodent, feline, and canine cell lines. Although the specific activities of r-metIFN-con1 and IFN-γ2a differed 10-fold, the host range was very similar. The host range of IFN-β differed from that of r-metIFN-con1 and IFN-α2a in that Vero cells were 100-fold better protected by IFN-β and MDBK protected at a 100-fold less efficiency. In general, there were only minor differences between the host ranges of the three interferons, human and primate cells being better protected than those of other species. However, the tissue of origin of the cell appears to be more important than the species of origin in defining host range.Keywords
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