Modulation of 7,12‐Dimethylbenz[a]anthracene‐induced Transmammary Carcinogenesis by Disulfiram and Butylated Hydroxyanisole in Mice
- 1 December 1989
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 80 (12) , 1171-1175
- https://doi.org/10.1111/j.1349-7006.1989.tb01650.x
Abstract
The individual as well as combined chemopreventive actions of disulfiram (DSF) and butylated hydroxyanisole (BHA) on 7,12-dimethylbenz.alpha.]anthracene (DMBA)-induced transmammary carcinogenesis in mice were examined. When nursing mothers receiving normal diet were treated with DMBA (1 mg/mouse) on days 6, 8 and 10 postpartum, the tumor incidence in their 50-week-old F1 progeny was 44.1%. When nursing mothers receiving 0.75% BHA diet, 0.5% DSF diet and 0.75% BGA+0.5% DSF diet were similarly treated with DMBA, the tumor incidences in their 50-week-old F1 progeny were 14.7% (P < 0.05), 12.5% (P < 0.05) and 5.8% (P < 0.01), respectively. It is concluded that diets containing BHA (0.75%) and DSF (0.5%), singly or in combination, can inhibit transmammary carcinogenesis in Swiss albino mice.Keywords
This publication has 40 references indexed in Scilit:
- Disulfiram Prevents Acetaminophen Hepatotoxicity in RatsBasic & Clinical Pharmacology & Toxicology, 1988
- Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachlorideChemico-Biological Interactions, 1988
- Use of diethyldithiocarbamate as a probe to detect stable intermediates during the decomposition of several mutagenic and nonmutagenic N-nitroso compoundsZeitschrift für Krebsforschung und Klinische Onkologie, 1986
- Inhibitory action of BHA on carcinogenesis in F1 and F2 descendants of mice exposed to DMBA during pregnancyInternational Journal of Cancer, 1982
- Effect of butylated hydroxyanisole on the metabolism of benzo[a]-pyrene and the binding of metabolites to DNA, in vitro and in vivo, in the forestomach, lung, and liver of miceCarcinogenesis: Integrative Cancer Research, 1982
- Inhibition of Carcinogen Metabolism and Action by Disulfiram, Pyrazole, and Related CompoundsPublished by Springer Nature ,1981
- Effect of 2(3)-tert-butyl-4-hydroxyanisole administration on the activities of several hepatic microsomal and cytoplasmic enzymes in miceBiochemical Pharmacology, 1979
- Induction of rat hepatic epoxide hydratase by dietary antioxidantsToxicology and Applied Pharmacology, 1979
- Effects of disulfiram and related compounds on the metabolism in vivo of the colon carcinogen, 1,2-dimethylhydrazineBiochemical Pharmacology, 1977
- Inhibition of the mono-oxygenase system by butylated hydroxyanisole and butylated hydroxytolueneLife Sciences, 1974