DNA Synthesis as a Marker in Fractionated Radiation Therapy
- 1 February 1963
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 80 (2) , 244-250
- https://doi.org/10.1148/80.2.244
Abstract
Exposure to ionizing radiations produces a marked suppression of DNA synthesis by mouse tumor. This is predominantly due to a decrease in the number of cells in the synthesis phase. This suppression lasts several days and is followed by a recovery and rebound on the third to the fifth day. Human tumors show a similar cyclic change after irradiation. Normal intestinal mucosa follows a similar suppression-recovery rebound pattern but with a shorter interval. The possibility of increasing effect by synchronizing radiation exposures with the rebound phase is suggested.Keywords
This publication has 1 reference indexed in Scilit: