Hyperactivity and Brain Catecholamines in Lead-Exposed Developing Rats
- 7 December 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4116) , 1022-1024
- https://doi.org/10.1126/science.182.4116.1022
Abstract
Newborn rats that suckled mothers eating a diet containing 4 percent lead carbonate display hyperactivity, aggressiveness, and excessive stereotyped behavior starting at 4 weeks of age. There is an eightfold increase in the concentration of lead in brain, no change in norepinephrine, but a 20 percent decrease in dopamine relative to coetaneous controls. This suggests a relationship between central nervous system dysfunction due to lead and dopamine metabolism in brain.Keywords
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