In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva
- 1 March 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 24 (3) , 295-299
- https://doi.org/10.1021/jm00135a011
Abstract
A variety of naphthoquinones have been prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever (T. parva) infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety is essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl or tetradecyl.This publication has 3 references indexed in Scilit:
- In vitrostudies on the action of menoctone and other compounds onTheileria parvaandT. annilataPathogens and Global Health, 1978
- The Susceptibility of the African Buffalo ( Syncerus Caffer ) to Infection with Theileria Parva (Theiler 1904) 1 1This work is based on part of a thesis submitted by D. W. B. to the University of Zurich for the degree of Dr. Vet. Med.British Veterinary Journal, 1966
- Naphthoquinone Antimalarials. I. General Survey1,2Journal of the American Chemical Society, 1948