Scintigraphy in Uremic Bone Disease

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Abstract
The tissue distribution of 99Tcm-PP [polyphosphate] is poorly understood; it is bound to serum proteins and erythrocytes and is primarily excreted by renal elimination. In a patient''s skeleton with low mineral density woven bone, as in uremic osteodystrophy, the presence of fibrous bone may be a major determinant of the local rate of isotope uptake. Thus, isotope uptake does not directly measure bone apposition but indirectly measures consequences of bone apposition which may be dissociated from it in metabolic bone disease.

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