CYTOGENETICS OF FIBROBLASTIC COLONIES IN PH1-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 51  (6) , 1039-1044
Abstract
The cytogenetic status of bone marrow stromal elements obtained form 6 patients with Ph1-positive chronic myelogenous leukemia (CML), 2 in blast crisis, was studied in vitro utilizing the potential of marrow to form surface-adherent colonies morphologically compatible with mesenchymal elements. The absence of the marker chromosome and other chromosomal abnormalities were demonstrated in all the fibroblastic colonies studied, indicating that the progenitors of such colonies (plaque-forming units in culture, PFU-C) are not closely related to hematopoietic elements including macrophages. The stromal elements in myelofibrosis associated with CML are probably not derived from the primary Ph1-positive malignant clone; they may represent a stromal reactive component of benign or independent malignant potential.

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