Alterations in the Characteristics of Sugar Uptake by Mouse Cells Transformed by Murine Sarcoma Viruses2

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Abstract
Mouse-embryo tissue cultures infected with and transformed by murine sarcoma viruses (MSV) showed significant increases in the rate of uptake of glucose, mannose, and galactose. This uptake was characterized by a Km value approximately tenfold lower than that of uninfected mouse cells, cells infected with murine leukemia viruses, or SV40-transformed 3T3 cells. By contrast, and perhaps surprisingly, 3-0-methylglucose uptake was characterized by a Km value significantly higher for the sarcoma virus-infected cells. The data suggest virus-specific membrane alterations that may be useful in assigning a viral etiology to spontaneous sarcomas in mice.

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