Lack of in vitro antiviral activity of fluoroquinolones against herpes simplex virus type 2
- 1 September 1992
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 122 (3-4) , 263-269
- https://doi.org/10.1007/bf01317188
Abstract
The antiviral activity against herpes simplex virus type 2 (HSV-2) of five fluoroquinolones (ciprofloxacin, lomefloxacin, ofloxacin, pefloxacin, rufloxacin) was tested in vitro. Their efficacy was evaluated as reduction of the cytopathic effect (CPER) exerted by HSV-2 on Vero cells in comparison with novobiocin and acycloguanosine. Our results show a very poor antiviral effect of five quinolones (CPER50=200 mg/l) that was comparable with their cytotoxicity (TCIC5050 mg/l). Our data suggest that fluoroquinolones cannot be considered drugs able to inhibit HSV-2 replication in vitro.Keywords
This publication has 21 references indexed in Scilit:
- Role of DNA topoisomerase I in the replication of herpes simplex virus type 2Archiv für die gesamte Virusforschung, 1990
- Effect of fluoroqmnolones on the in-vitro proliferation of myeloid precursor cellsJournal of Antimicrobial Chemotherapy, 1989
- 4-quinolone antibiotics: Positive genotoxic screening tests despite an apparent lack of mutation inductionMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- Effects of quinolones on mitogen-stimulated human mononnclear leucocytesJournal of Antimicrobial Chemotherapy, 1988
- Antiviral activity and inhibition of topoisomerase by ofloxacin, a new quinolone derivativeAntiviral Research, 1987
- Studies on DNA Topoisomerases I and II in Herpes Simplex Virus Type 2-infected CellsJournal of General Virology, 1987
- Effects of the Epipodophyllotoxin VP-16-213 on Herpes Simplex Virus Type 2 ReplicationJournal of General Virology, 1987
- DNA topoisomerase II: A primer on the enzyme and its unique role as a multidrug target in cancer chemotherapyPharmacology & Therapeutics, 1987
- 9-anilinoacridines: Novel compounds active against herpes simplex virusChemico-Biological Interactions, 1985
- Early inhibition of human cytomegalovirus replication by novobiocinJournal of Antimicrobial Chemotherapy, 1982