The Effect of Ionizing Radiations on the Electrophoretic Mobility of Mammalian Cells

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Abstract
The effects of x- and γ-radiations on the electrophoretic mobility of a variety of mammalian cell-lines, including embryonic and L-strain mouse fibroblasts, monkey kidney cells, human amnion, human red cells and also the Davidson, DiVita, Ehrlich-Landschütz and Lettré strains of murine ascites-tumour cell, are reported. The suspensions of cells were prepared in a number of ways under various experimental conditions. The effects of the presence of low concentrations of cupric and zinc ions and of EDTA during these studies are also presented. In no instance did irradiation of the cells with low doses, up to circa 1000 rads, produce statistically significant changes in their electrophoretic characteristics. The results are compared with those obtained in a previous investigation, and it is concluded that infection of the cells used then may have been responsible for the observed effects. Doses of >2000 rads produced a decrease in electrophoretic mobility of tumour cells but not of red blood cells.