Characterization of bacterial cytochrome cd1-nitrite reductase as one enzyme responsible for catalysis of nitrosation of secondary amines
Open Access
- 1 March 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 17 (3) , 533-536
- https://doi.org/10.1093/carcin/17.3.533
Abstract
Bacterial formation of carcinogenic N-nitroso compounds may play a role in the etiology of human cancer. Biochemical and immunological studies in denitrifying bacteria (Pseudomonas aeruginosa) strongly support the identification of cytochrome cd1-nitrite reductase as the enzyme responsible for the catalysis of nitrosation through the production of nitric oxide or NO+-like species. Interestingly, electron paramagnetic resonance studies have shown that large quantities of nitric oxide or NO+-like species were also produced by non-denitrifying enterobacteria (Escherichia coli, Proteus morganii).Keywords
This publication has 0 references indexed in Scilit: