Experimental myocarditis. I. Cardiac lesions in rats induced by immunization with homologous heart extracts.
Open Access
- 1 January 1980
- journal article
- Published by Japanese Circulation Society in Japanese Circulation Journal
- Vol. 44 (10) , 833-837
- https://doi.org/10.1253/jcj.44.833
Abstract
The production of myocardial lesions and circulating anti-heart antibodies has been studied in rats injected with homologous heart extracts emulsified with the Freund's complete adjuvant and the DTP vaccine. Six of 7 rats showed lesions of focal myocarditis, while only in one of them circulating anti-heart antibodies were detected. There was no correlation between the presence of circulating anti-heart antibodies and that of myocardial lesions. These findings suggested that the circulating anti-heart antibodies may play little or no role in the pathogenesis of this experimental myocarditis.Keywords
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