Ultrafiltration of Calcium and Strontium from Sera of Patients with Protein Abnormalties Studied with the Radioisotope Technique1
- 1 October 1963
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 23 (10) , 981-985
- https://doi.org/10.1210/jcem-23-10-981
Abstract
The ultrafilterability of calcium and strontium from sera of patients with multiple myeloma and of patients with Boeck's sarcoidosis was studied by the use of tracer doses of Ca45 and Sr85. The results were compared with those obtained with sera of normals. The average values of ultrafilterable calcium and strontium for normals were 55.1% for Ca45 and 67.1% for Sr85, with an average Sr85/Ca45 ratio of 1.22. The filtration of Ca45 from sera of patients with multiple myeloma was somewhat higher than that of normals, and the ultrafiltration of Sr85 was slightly but not significantly increased. This indicated decreased binding of both elements to the abnormal proteins. The Sr85/Ca45 ratio was lower than that of normals because of the relatively higher filtration of Ca45. Sera of patients with Boeck's sarcoidosis with normal and abnormal serum protein distribution had approximately the same filterability of Sr85 as normals and a lower filterability of Ca45 (at a 5% level of significance). However, the lower filterability of Ca45 was suggestive rather than diagnostic because of the heterogeneity of this group of patients and the variability of Ca45 filtration from patient to patient. The results of the ultrafiltration studies with Ca45 are in good agreement with those obtained with stable calcium and with larger amounts of ultrafiltrate.Keywords
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