Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice
Open Access
- 25 February 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (4) , 1423-1430
- https://doi.org/10.1093/nar/16.4.1423
Abstract
Transgenic mice were generated carrying either the long terminal repeat of Human Immunodeficiency Virus fused to the bacterial chloramphenicol acetyl transferase reporter gene or a control element of the murine αA crystallin gene fused to the tat gene of human immunodeficiency virus. By crossing these two strains, progeny were obtained which carried both transgenes. The bacterial reporter gene was specifically transactivated in the eyes of these animals.Keywords
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