CONTRIBUTORY FACTORS IN POSTARSPHENAMIN DERMATITIS

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Abstract
Since the organization of the Section on Dermatology and Syphilology of the Mayo Clinic, 44,000 injections of arsphenamin have been given, and approximately thirty-eight cutaneous reactions of various types have been observed. Of this number, thirty-three were studied carefully enough, even in the earlier days of the departmental organization, to permit their use as material for the basis of certain impressions on the etiologic background and therapeutic control of these reactions. It is not our intention merely to repeat the details of description and classification which have been so completely covered in numerous and excellent contributions to the subject by various American and foreign writers. Our concern has been mainly prevention and treatment and the study of the etiologic background in order to rationalize our therapeutic procedures. Our principal observations concern the relation of focal and intercurrent infection to the production and the course of cutaneous reactions to arsphenamin. They

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