Update: The Effect of Interleukin-1 on the Thyroid Gland
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Autoimmunity
- Vol. 16 (2) , 141-148
- https://doi.org/10.3109/08916939308993319
Abstract
The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.Keywords
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