Determinants of Allograft Survival in 100 Consecutive Cadaver Kidney Transplants

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Abstract
Consecutive cadaver renal transplants (100) performed between April 1976-Oct. 1979 were reviewed. A minimum 1 yr followup was available on all patients. The actual 1 yr graft survival rate was 64% and the actual 1 yr patient survival rate was 91%. Criteria that had no significant effect on 1 yr allograft survival were performance of pretransplant nephrectomy and/or splenectomy, red blood cell group or the level of pre-formed antibody. A major determinant of graft survival was the number of blood transfusions received before transplantation. The 1 yr graft survival rate was 36% with no pretransplant transfusions, 64% with 1-5 transfusions and 70% with > 5 transfusions (P < 0.005). The 1 yr graft survival rate was not influenced by the use of kidneys imported from other states, the use of pediatric cadaver donors 1-15 yr old or extended renal preservation times. The continued regional and national sharing of adult and pediatric cadaver donor kidneys with extended preservation times was supported.