Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore
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- 29 April 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (20) , 6548-6549
- https://doi.org/10.1021/ja060399c
Abstract
Novel ratiometric fluorescent probes for Zn2+ in the near-infrared region, based on a tricarbocyanine chromophore, have been designed, synthesized, and evaluated. Upon addition of Zn2+, a 44 nm red shift of the absorption maximum was observed, which indicates that this probe could work as a ratiometric probe for Zn2+. This change is due to the difference in the electron-donating ability of the amine substituent before and after reaction with Zn2+. This fluorescence modulation of amine-substituted tricarbocyanines should be applicable to dual-wavelength measurement of various biomolecules or enzyme activities.Keywords
This publication has 12 references indexed in Scilit:
- QZ1 and QZ2: Rapid, Reversible Quinoline-Derivatized Fluoresceins for Sensing Biological Zn(II)Journal of the American Chemical Society, 2005
- Evolution of Fluorescein as a Platform for Finely Tunable Fluorescence ProbesJournal of the American Chemical Society, 2005
- A Dual Fluorochrome Probe for Imaging ProteasesBioconjugate Chemistry, 2004
- The Rhodafluor Family. An Initial Study of Potential Ratiometric Fluorescent Sensors for Zn2+Inorganic Chemistry, 2002
- A Novel, Cell-Permeable, Fluorescent Probe for Ratiometric Imaging of Zinc IonJournal of the American Chemical Society, 2002
- Improvement and Biological Applications of Fluorescent Probes for Zinc, ZnAFsJournal of the American Chemical Society, 2002
- In vivo near-infrared fluorescence imaging of osteoblastic activityNature Biotechnology, 2001
- In vivo molecular target assessment of matrix metalloproteinase inhibitionNature Medicine, 2001
- Infrared fluorescence sensing of submicromolar calcium: pushing the limits of photoinduced electron transferTetrahedron Letters, 2000
- Multidentate coordination compounds. Chelating properties of aliphatic amines containing .alpha.-pyridyl residues and other aromatic ring systems as donor groupsInorganic Chemistry, 1968