Laboratory and Clinical Studies of Some Quinol Diphosphates and Related Compounds as Chemical Radiosensitizers and the Development of a Radioactive Drug (Part 1 of 4)
- 1 January 1961
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 3 (3) , 225-244
- https://doi.org/10.1159/000219546
Abstract
This paper is an account of the investigation of chemical radiosensitizers and the development of a radioactive drug. About 170 compounds were studied. The best chemical radiosensitizer is tetrasodium 2-methyl-I 4-naphthaquinol diphosphate, Synkavit (Compound I). Compound I is also the carrier molecule in the tritiated drug. An account is given of clinical investigations and associated laboratory studies, with particular reference to the use of preparations of tetrasodium 2-methyl-I: 4-naphthaquinol (6-T) diphosphate (TRA 72).Keywords
This publication has 2 references indexed in Scilit:
- Chemical stimulation and modification of glucose metabolism by brainArchives of Biochemistry and Biophysics, 1960
- Intra-arterial Therapy: A Review of its Clinical Applications in Malignant DiseaseThe British Journal of Radiology, 1960