Effectiveness of DTPA Treatments Following the Injection of Particulate Plutonium
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 60 (5) , 803-818
- https://doi.org/10.1080/09553009114552611
Abstract
A limited long-term experiment has been completed in which the chronic toxicity resulting from a single intravenous injection of 31·4 kBq of a poly-disperse 239Pu colloid sol per kg of body weight was tested in Beagle dogs. The Pu deposited mostly in the phagocytic cells of liver, spleen and to a lesser degree in lung and bone marrow. Slow solubilization of the Pu particles by endogenous ligands caused translocation of the nuclide and redeposition mostly as monomeric Pu in the skeleton and in liver hepatocytes. Thus, the deposit behaved as expected from a pulmonary or wound contamination in humans with a moderately soluble depot of Pu such as Class W hot particles. Therefore, this type of deposit provided the basis for a practical model to study the ensuing radiation effects under various experimental conditions. The dogs were divided into three groups of four animals each, and the following conditions were applied: (a) no further treatment was given, allowing free translocation of the Pu to its secondary deposition sites; (b) interception of the Pu translocation by weekly injections of 30 μmol of Ca-DTPA/kg of body weight (Ca-chelate of diethylene-triaminepentaacetic acid); and (c) interception of translocation by daily injections of 30 µmol/kg body weight of Zn-DTPA. For each of the groups (b) and (c), three dogs were used in a lifetime study, and one was sacrificed for nuclide distribution studies. Free translocation and subsequent deposition in the skeleton resulted in the death of each of the non-chelated dogs from osteosarcoma between 1267 and 1594 days after injection. Weekly treatment with Ca-DTPA reduced the total Pu burden significantly, but these dogs also died with osteosarcoma between 1462 and 1783 days. Daily injections with Zn-DTPA reduced the total Pu burden more efficiently than Ca-DTPA and prevented continuous deposition of solubilized Pu on bone surfaces. The mean post-injection survival of these dogs was 3520 days or about 2·1 times that of the animals receiving Ca-DTPA, while the latent period for bone tumour induction was about 2·6 times longer. This treatment reduced the severity of liver lesions and eliminated the occurrence of persistent leukopenia, but it did not prevent the formation of bone cancer.Keywords
This publication has 13 references indexed in Scilit:
- 1976 Hanford Americium Exposure IncidentHealth Physics, 1983
- Oral Chelation Treatment of Injected 241Am Or 239Pu in RatsHealth Physics, 1980
- Removal of Plutonium from Beagles Using Ca-DTPA and Zn-DTPAHealth Physics, 1978
- Decorporation from Beagles of a Mixture of Monomeric and Particulate Plutonium Using Ca-DTPA and Zn-DTPAHealth Physics, 1978
- Influence of Inhaled Ca-DTPA on the Long-term Effects of Inhaled Pu NitrateHealth Physics, 1977
- Distribution and Excretion of Three Chemical Species of 239Pu(IV) in the BeagleHealth Physics, 1975
- Influence of DTPA Therapy on Long-Term Effects of Retained Monomeric Plutonium: Comparison with Polymeric PlutoniumRadiation Research, 1967
- Influence of DTPA Therapy on Long-term Effects of Retained PlutoniumHealth Physics, 1962
- The Skeletal Toxicity of Pu239 in Adult BeaglesHealth Physics, 1962
- Alpha-ray Dosage in Bone Containing RadiumThe British Journal of Radiology, 1953