Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium.

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Abstract
Acute myocardial infarctions were produced in 11 dogs by ligation of the left anterior descending coronary artery. Twenty-four hours after ligation, 0.35 mmol/kg of Gd-DTPA [gadolinium-diethylenetriaminepentaacetic acid] was injected i.v., followed by cardiectomy either 90 s (3 dogs) or 5 min (5 dogs) later. The remaining 3 dogs had cardiectomy without injection of Gd-DTPA at 24 h after coronary occlusion. The 3 dogs that did not receive Gd-DTPA had longer T1 and T2 relaxation times in infarcted myocardium than in normal myocardium, as measured by a 10.7-MHz magnetic resonance (MR) spectrometer. The T1 and T2 relaxation times of normal myocardium at 90 s postinjection of Gd-DTPA were significantly shorter (P < 0.05) than those of the normal myocardium of animals that did not receive Gd-DTPA. At 5 min postinjection, significantly (P < 0.01) greater T1 shortening was exhibited in the infarcted myocardium compared with adjacent normal myocardium in the dogs injected with Gd-DTPA. Gd-DTPA has differential and time-varying effects on relaxation times of normal and infarcted myocardium.

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