CONNECTIVE-TISSUE ACTIVATION .12. PLATELET ABNORMALITIES IN PATIENTS WITH RHEUMATOID-ARTHRITIS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 5  (2) , 177-183
Abstract
Patients with rheumatoid arthritis frequently have an unexplained thrombocytosis which appears to be related to the severity of the disease process. Rheumatoid platelets have reduced saline soluble protein/109 platelets, less of a lysosomal enzyme, acid phosphatase, and decreased connective tissue activating peptide (CTAP-III) activity. CTAP-III is a potent connective tissue mitogen, and promotes glycolysis and glycosaminoglycan synthesis, characteristics which make it an interesting candidate for a role as a mediator of inflammation.

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