Unambiguous synthesis of 1-(7-indenyloxy)-3-isopropylamino-2-propanol hydrochloride and its 4-indenyloxy isomer, potent .BETA.-adrenergic blocking agents.

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Abstract
1-(7-Idenyloxy)-3-isopropylamino-2-propranol hydrochloride [YB-2] (Ia) and its 4-idenyloxy isomer (IIa) were synthesized through the sequence of reactions in which possible isomerization of the indene nucleus was prevented by avoiding alkaline conditions. YB-2 synthesized by this method was a 2:1 mixture of Ia and IIa. tert-Butyl analogue of Ia and IIa was prepared similarly. Biological activities of Ia and IIa were compared with those of YB-2 in rats and dogs.

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