GLOMERULAR CHANGES IN DENGUE HEMORRHAGIC-FEVER

Google Scholar
  • 1 January 1976
    • journal article
    • research article
    • Vol. 100  (4) , 206-212
Abstract
Percutaneous needle bipsies were performed on the kidneys of 20 patients who had dengue hemorrhagic fever with some clinical manifestation of renal impairment. In ten cases, IgG [immunoglobulin G], IgM, or both, and C3 [complement component 3] could be localized in the glomeruli, using the fluorescent antibody technique. In those cases in which immune complex was found, the biopsy was done in the 2nd wk after the onset of fever. EM showed focal thickening of the glomerular basement membrane with hypertrophy of mesangial cells at the sites where the immune complex was shown. Dense spherical particles, 40-50 nm in diameter, were found in 12 cases. Those particles were carried into the glomeruli by monocyte-like cells.

This publication has 2 references indexed in Scilit: