EFFECTS OF CHRONIC TREATMENT WITH PROPRANOLOL ON BLOOD-PRESSURE AND CARDIOVASCULAR REACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 227  (1) , 30-40
Abstract
Young SHR [spontaneously hypertensive rats] were treated with propranolol (16 or 64 mg/kg per day) from 6-14 wk of age. Systolic blood pressure was significantly lower in SHR treated with propranolol (64 mg/kg) than in untreated SHR; no effect was seen in SHR treated with 16 mg/kg. Hemodynamic characteristics of hindquarter vascular beds did not significantly differ between untreated and propranolol-treated SHR. Adult SHR were given propranolol (64 mg/kg per day) from 5-8 mo. of age. Moderate reduction of systolic blood pressure was observed from 2-3 mo. of propranolol treatment. Cardiovascular pressor response to noradrenaline [norepinephrine] decreased in propranol-treated SHR, while decreased responsiveness was not found after pithing.