Radiation Chemistry of DNA, II. Strand Breaks and Sugar Release by γ-Irradiation of DNA in Aqueous Solution. The Effect of Oxygen
Open Access
- 1 December 1975
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 30 (11-12) , 826-828
- https://doi.org/10.1515/znc-1975-11-1225
Abstract
From γ-irradiated oxygenated aqueous solutions of DNA, 2-deoxy-tetrodialdose (1) and 2-deoxy-pentos-4-ulose (2) have been isolated as free sugars. The formation of 1 indicates that in the presence of oxygen the DNA strand is not only broken by mere phosphate ester cleavage but also by C -C-bond rupture in the sugar moiety. Such a process has not been encountered in deoxygenated solutions so far. The mechanism for the formation of 1 is discussed.Keywords
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