Haemodynamic Stability during Anaesthesia Induction and Sternotomy in Patients with Ischaemic Heart Disease

Publisher Website
Google Scholar
Abstract
A comparison of hemodynamic stability with respect to arterial pressure, heart rate and cardiac output between 6 commonly used anesthetic techniques: fentanyl (FE), halothane (HAL), morphine (MO), fentanyl/droperidol (NLA) and thiopentone (2 dose levels: PE 3 and PE 6), all supplemented with nitrous oxide, was performed during induction of anesthesia and sternotomy in 47 patients with good left ventricular function and maintained .beta.-blockers undergoing coronary bypass surgery. Interventions were kept to a minimum to characterize each anesthesia group. Statistically, the material fell into 2 parts. The MO, PE 3 and PE 6 groups showed good stability under steady-state anesthesia, but variable and often extensive hyperdynamic responses were seen to endotracheal intubation and surgical stimulation. The PE, HAL and NLA groups were characterized by a good stability during the induction-intubation phase but were unstable when combined with nitrous oxide in the absence of noxious stimuli.