Relationship between the Inhibitory Activity on 'RCS' and Prostaglandins Synthesis and the Anti-Inflammatory Activity of Ketoprofen and Several other Non-Steroidal Anti-Inflammatory Agents
- 1 January 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 15 (5) , 11-14
- https://doi.org/10.1093/rheumatology/15.5.11
Abstract
In this study ketoprofen has been shown to be the most potent of all anti-inflammatory drugs in inhibiting the synthesis of prostaglandins and the ‘rabbit-aorta contracting substance’ (RCS), using the guinea-pig lung preparation. Although there did not appear to be a close relationship between the activities of the various drugs in inhibiting prostaglandins synthesis and in their anti-inflammatory activity, the compounds were ranked in the same order in both test systems.Keywords
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