Platelet and Plasma Fibrinogens Are Identical Gene Products
- 26 July 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4148) , 368-370
- https://doi.org/10.1126/science.185.4148.368
Abstract
Human platelet fibrinogen has been shown to be indistinguishable from plasma fibrinogen by a variety of criteria, including subunit composition and cross-linking characteristics as judged by sodium dodecyl sulfate-gel electrophoresis, quantitative amino terminal analysis of fibrin, and the amino acid compositions of fibrinopeptides. The structural identity of the fibrinopeptides released from platelet and plasma fibrinogens is consistent with the two proteins being products of the same gene or genes.Keywords
This publication has 26 references indexed in Scilit:
- Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombinBiochemistry, 1974
- Fibrinogen Associated with Subcellular Platelet ParticlesScandinavian Journal of Haematology, 1973
- γ-γ Cross-linking sites in human and bovine fibrinBiochemistry, 1971
- Heterogeneity of human fibrinogen: Possible relation to proteolysis by thrombin and plasmin as studied by SDS-polyacrylamide gel electrophoresisBiochemical and Biophysical Research Communications, 1970
- Effect of proteolytic activity on the isolation and stability of platelet proteinsClinica Chimica Acta; International Journal of Clinical Chemistry, 1969
- Immunological Studies of Proteins Associated with the Subcellular Fractions of Thrombasthenic and Afibrinogenaemic PlateletsBritish Journal of Haematology, 1968
- Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gelsBiochemical and Biophysical Research Communications, 1967
- Human fibrinopeptides isolation, characterization and structureBiochimica et Biophysica Acta (BBA) - General Subjects, 1966
- Platelet fibrinogenJournal of Clinical Pathology, 1965
- Amino-Acid Sequence Investigations of Fibrinopeptides from Various Mammals: Evolutionary ImplicationsNature, 1964