THE SIGNIFICANCE OF MUCOPOLYSACCHARIDES IN AMYLOID

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Abstract
Amyloid was extracted from six amyloid-laden organs of four different diseases: familial Mediterranean fever (FMF), Hodgkin's disease, rheumatoid arthritis and tuberculosis. In the case of FMF amyloid extracts of three different organs of the same patient were prepared. Chemical studies have indicated the identity of the mucopolysaccharide composition in the amyloid preparations, the amyloid-laden organs and normal organs. The differences were limited to the amounts of the mucopolysaccharide components. The metachromatic properties of an amyloid preparations were not directly related to the level of mucopolysaccharides present. The protein of the amyloid fibers was found to differ chemically from the core protein of chondromucoprotein.

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