Apocrine gland adenoma and adenocarcinoma of the axilla

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Abstract
Apocrine tumors from the axilla of 12 patients were studied clinically and pathologically. Based on histologic features, 2 tumors were classified as adenomas and 10 as adenocarcinomas. All of the neoplasms were characterized by a glandular arrangement of large cells with abundant eosinophilic cytoplasm and evidence of decapitation secretion. The cytoplasm of the tumor cells contained PAS[periodic acid Schiff]-positive, diastase-resistant granules. Intracytoplasmic particles of Fe were demonstrable in 3 of 10 tumors. Follow-up was available for all 12 patients. The 2 patients with apocrine adenoma are alive and well. Two patients with adenocarcinoma died of unrelated causes shortly after diagnosis. Of the remaining 8 patients with adenocarcinoma, 3 died of disease, and 1 is living with skeletal metastasis. A correlation appears to exist between tumor differentiation and prognosis.

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