Metabolism of Endogenous Proinsulin and Insulin in Man*
- 1 February 1974
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 38 (2) , 305-308
- https://doi.org/10.1210/jcem-38-2-305
Abstract
The disappearance of endogenous serum proinsulin and insulin was measured in 3 patients following removal of beta-cell adenomas of the pancreas. The mean half-disappearance time for proinsulin (17.2 min) was much longer than for insulin (4.8 min). This difference in the metabolic rate of the 2 hormones together with previously described differences in their hepatic extraction, are sufficient to explain the higher proinsulin :insulin ratio in serum compared to the pancreas.Keywords
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